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Thermo Scientific™ Lab Vision™ Topoisomerase II α Ab-1, Rabbit Polyclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ Topoisomerase II α Ab-1, Rabbit Polyclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  RB117P1ABX

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Catalog No. RB117P1ABX

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Description & Specifications

Specifications

Antigen Topoisomerase II alpha Ab-1
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blot
Applications Western Blotting
Classification Polyclonal
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Formulation Ab without BSA/Azide (Frozen)
Host Species Rabbit
Immunogen A synthetic peptide, corresponding to aa 1513-1530 (RAKKPIKYLEESDEDDLF) from the C-terminus of human topoisomerase IIalpha
Isotype IgG
Quantity 500μL
Regulatory Status RUO
Research Discipline DNA Repair
Type Primary
Monoclonal or Polyclonal Polyclonal
Target Species Human

Provide accurate, reproducible results with the Thermo Scientific™ Topoisomerase II α Ab-1, Rabbit Polyclonal Antibody.

Topo IIα plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Note that Ki67/M1B1 is also present in G1-phase. Topo IIα is also implicated in drug resistance of tumor cells.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human. Others not known.

Epitope: aa 1513-1530

Immunogen: A synthetic peptide, corresponding to aa 1513-1530 (RAKKPIKYLEESDEDDLF) from the C-terminus of human topoisomerase IIα

Molecular Weight: 170kDa

Positive Control: Raji cells or any exponentially growing cultured human cells

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry
  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation (Native and denatured)

Note:

USA: RUO; Int'l: RUO