Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic β-cells. The activity of various biotransformation enzymes in cultured primary rat proximal tubular cells in the presence of tolbutamide and other compounds has been studied.
Soluble in chloroform.
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.
|128° to 130°C|
Safety and Handling
GHS H Statement
Harmful if swallowed.
May cause an allergic skin reaction.
GHS P Statement
Avoid breathing dust/fume/gas/mist/vapors/spray.
Wear protective gloves/protective clothing/eye protection/face protection.
IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
Wash contaminated clothing before reuse.
Specific treatment (see label).
Dispose of contents/container in accordance with local/regional/national/international regulations.
RTECSNumber : YS4550000
TSCA : TSCA