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Thermo Scientific™ Lab Vision™ TIMP-2 Ab-5, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ TIMP-2 Ab-5, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS1485P1ABX

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Catalog No. MS1485P1ABX

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Description & Specifications

Specifications

Antigen TIMP-2 Ab-5
Applications Immunohistochemistry (Paraffin)
Applications Western Blotting
Classification Monoclonal
Clone 3A4
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Bovine
Cross Reactivity Guinea Pig
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rabbit
Cross Reactivity Rat
Format Concentrated
Formulation Ab without BSA/Azide (Frozen)
Host Species Murine
Immunogen A synthetic peptide from the N-terminal region of human TIMP-2 protein
Isotype IgG2a kappa
Quantity 100μL
Regulatory Status RUO
Research Discipline Proteases And Inhibitors
Type Primary
Monoclonal or Polyclonal Monoclonal
Target Species Bovine
Target Species Guinea Pig
Target Species Human
Target Species Murine
Target Species Rabbit
Target Species Rat

Provide accurate, reproducible results with the Thermo Scientific™ TIMP-2 Ab-5, Mouse Monoclonal Antibody.

TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.

Host Species: Mouse

Clone: 3A4

Isotype: IgG2a/κ

Species Reactivity: Human, Mouse, Rat, Rabbit, Cow and Guinea Ppig. Others not known.

Epitope: N-terminal

Immunogen: A synthetic peptide from the N-terminal region of human TIMP-2 protein

Molecular Weight: 21kDa

Positive Control: Conditioned, serum-free medium from (TPA-treated) HFL-1 cells; Pancreatic or colon CA

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin only)
  • Western Blotting
  • Immunoprecipitation (Not suitable)

Note:

USA: RUO; Int'l: RUO