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Thermo Scientific™ Lab Vision™ TIMP-2 Ab-1, Mouse Monoclonal Antibody

Provide accurate, reproducible results with the Thermo Scientific™ TIMP-2 Ab-1, Mouse Monoclonal Antibody.

$273.20 - $1,619.02

Specifications

Antigen TIMP-2 Ab-1
Clone T2-101
Applications Immunoprecipitation,Western Blotting,Immunoprecipitation,Western Blotting
Classification Monoclonal
Format Concentrated
View More Specs


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Specifications

Description

Provide accurate, reproducible results with the Thermo Scientific™ TIMP-2 Ab-1, Mouse Monoclonal Antibody.

Tissue inhibitor of metalloproteinases-1 (TIMP-1) and Tissue inhibitor of metalloproteinases-2 (TIMP-2) have similar properties, specifically in inhibiting enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.

Host Species: Mouse

Clone: T2-101

Isotype: IgG1

Species Reactivity: Human. Does not react with mouse and rat. Others not known.

Epitope: aa 111-126. This epitope is not involved in binding of TIMP-2 to MMP-2

Immunogen: Native human pro-MMP-2/TIMP-2 complex purified from A2058 culture medium followed by purified human rTIMP-2

Molecular Weight: 21kDa

Positive Control: Conditioned, serum-free medium from (TPA-treated) human fetal lung cell line HFL-1

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Not suitable)
  • Immunoprecipitation (Native and denatured)
  • Western Blotting

Note:

USA: RUO; Int'l: RUO

General References:

1. Hurskainen T, et. al. Human Pathology, 1996, 27(1):42-9.

2. Hurskainen T, et. al. Journal of Histochemistry and Cytochemistry, 1996, 44(12):1379-88.

3. Visscher DW, et. al. International Journal of Cancer, 1994, 59(3):339-44.

4. Hoyhtya M, et. al. International Journal of Cancer, 1994, 56(4):500-5.

Description & Specifications

Specifications

TIMP-2 Ab-1
Immunoprecipitation,Western Blotting,Immunoprecipitation,Western Blotting
Concentrated
RUO
Primary
IgG1
T2-101
Monoclonal
Murine
Proteases And Inhibitors
Native human pro-MMP-2/TIMP-2 complex purified from A2058 culture medium followed by purified human rTIMP-2