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Thermo Scientific™ Lab Vision™ TIMP-2 Ab-1, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ TIMP-2 Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS571P1ABX

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Catalog No. MS571P1ABX

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Description & Specifications

Specifications

Antigen TIMP-2 Ab-1
Applications Immunoprecipitation
Applications Western Blotting
Classification Monoclonal
Clone T2-101
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Host Species Mouse
Immunogen Native human pro-MMP-2/TIMP-2 complex purified from A2058 culture medium followed by purified human rTIMP-2
Isotype IgG1
Quantity 100µL
Regulatory Status RUO
Research Discipline Proteases And Inhibitors
Type Primary

Provide accurate, reproducible results with the Thermo Scientific™ TIMP-2 Ab-1, Mouse Monoclonal Antibody.

Tissue inhibitor of metalloproteinases-1 (TIMP-1) and Tissue inhibitor of metalloproteinases-2 (TIMP-2) have similar properties, specifically in inhibiting enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.

Host Species: Mouse

Clone: T2-101

Isotype: IgG1

Species Reactivity: Human. Does not react with mouse and rat. Others not known.

Epitope: aa 111-126. This epitope is not involved in binding of TIMP-2 to MMP-2

Immunogen: Native human pro-MMP-2/TIMP-2 complex purified from A2058 culture medium followed by purified human rTIMP-2

Molecular Weight: 21kDa

Positive Control: Conditioned, serum-free medium from (TPA-treated) human fetal lung cell line HFL-1

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Not suitable)
  • Immunoprecipitation (Native and denatured)
  • Western Blotting

Note:

USA: RUO; Int'l: RUO