Thermo Scientific™ Lab Vision™ TIMP-2 Ab-1, Mouse Monoclonal Antibody
Provide accurate, reproducible results with the Thermo Scientific™ TIMP-2 Ab-1, Mouse Monoclonal Antibody.
Manufacturer: Thermo Scientific™ Lab Vision™ MS571P1ABX
Provide accurate, reproducible results with the Thermo Scientific™ TIMP-2 Ab-1, Mouse Monoclonal Antibody.Tissue inhibitor of metalloproteinases-1 (TIMP-1) and Tissue inhibitor of metalloproteinases-2 (TIMP-2) have similar properties, specifically in inhibiting enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
Host Species: Mouse
Species Reactivity: Human. Does not react with mouse and rat. Others not known.
Epitope: aa 111-126. This epitope is not involved in binding of TIMP-2 to MMP-2
Immunogen: Native human pro-MMP-2/TIMP-2 complex purified from A2058 culture medium followed by purified human rTIMP-2
Molecular Weight: 21kDa
Positive Control: Conditioned, serum-free medium from (TPA-treated) human fetal lung cell line HFL-1
Cellular Localization: Cytoplasmic
- Immunohistochemistry (Not suitable)
- Immunoprecipitation (Native and denatured)
- Western Blotting
USA: RUO; Int'l: RUO
|Native human pro-MMP-2/TIMP-2 complex purified from A2058 culture medium followed by purified human rTIMP-2|
|Proteases And Inhibitors|