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Thermo Scientific™ Lab Vision™ Tid-1 Ab-2, Mouse Monoclonal Antibody

Provide accurate, reproducible results with the Thermo Scientific™ Tid-1 Ab-2, Mouse Monoclonal Antibody.

Manufacturer:  Thermo Scientific™ Lab Vision™ MS1564PABX

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Catalog No. MS1564PABX


 

Specifications

Description

Provide accurate, reproducible results with the Thermo Scientific™ Tid-1 Ab-2, Mouse Monoclonal Antibody.

TID1 is a human homolog of the Drosophila tumor suppressor lethal (2) tumerous imaginal discs, l(2)tid and encodes two mitochondrial matrix localized splice variants of human Tid-1 designated hTid-1S and hTid-1L. These proteins are the conserved members of the DnaJ family of proteins which act as cochaperons for mitochondrial Hsp70. They contain a conserved tetrahedrical J domain which binds to Hsp70 chaperones and activates their ATPase activity. Expression of hTid-1L increases apoptosis induced by DNA damaging agents as mitomycin-C and TNF-α. A J-domain mutant of hTid-1L can dominantly suppress apoptosis and in sharp contrast the J-domain mutant of hTid-1S increases apoptosis. Expression of hTid-1S and hTid-1L affects cytochrome c release from the mitochondria and caspase 3 activation, while activation of caspase 8 is unaffected. It is strongly suggested that these two splice variants exert their anti- and pro- apoptotic effects through discrete substrates and actiuvities. Hence the relative abundance of these proteins or their substrates may allow the mitochondria to dampen or enhance the apoptotic signals.

Host Species: Mouse

Clone: RS13

Isotype: IgG1/κ

Species Reactivity: Human, Mouse and Rat. Others not known.

Immunogen: Recombinant hTid-1 protein

Molecular Weight: 40 and 43kDa

Positive Control: HeLa and Jurkat cells

Cellular Localization: Mitochondria

Recommended for:

  • Western Blotting
  • Immunoprecipitation

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

Tid-1 Ab-2
Monoclonal
1mg/mL
Human,Mouse,Rat
Murine
IgG2a kappa
200μL
Apoptosis
Monoclonal
Immunoprecipitation,Western Blotting
RS13
Unlabeled
Concentrated
Recombinant hTid-1 protein
HeLa and Jurkat cells
RUO
Primary
Human,Murine,Rat