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Thermo Scientific™ Lab Vision™ Thymidylate Synthase Ab-1, Mouse Monoclonal Antibody


Provide accurate, reproducible results Thermo Scientific™ Thymidylate Synthase Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS471P1ABX

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Catalog No. MS471P1ABX

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Description & Specifications

Specifications

Quantity 100µL
Format Concentrated
Regulatory Status RUO
Clone TS 106
Applications Flow Cytometry
Applications Immunofluorescence
Applications Immunoprecipitation
Applications Western Blotting
Antigen Thymidylate Synthase Ab-1
Cross Reactivity Human
Immunogen Recombinant human TS enzyme
Host Species Mouse
Isotype IgG2a kappa
Conjugate Unlabeled
Classification Monoclonal
Research Discipline DNA Repair
Type Primary
Concentration 1mg/mL

Provide accurate, reproducible results Thermo Scientific™ Thymidylate Synthase Ab-1, Mouse Monoclonal Antibody.

Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Host Species: Mouse

Clone: TS 106

Isotype: IgG1/κ

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Recombinant human TS enzyme

Molecular Weight: 36kDa

Positive Control: 5-FU-resistant cell cancer lines or colon CA

Cellular Localization: Nuclear and cytoplasmic

Recommended for:

  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation (Native verified)
  • ELISA
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO