Thermo Scientific™ Lab Vision™ Thymidylate Synthase Ab-1, Mouse Monoclonal Antibody
Provide accurate, reproducible results Thermo Scientific™ Thymidylate Synthase Ab-1, Mouse Monoclonal Antibody.
Manufacturer: Thermo Scientific™ Lab Vision™ MS471P1ABX
Provide accurate, reproducible results Thermo Scientific™ Thymidylate Synthase Ab-1, Mouse Monoclonal Antibody.Thymidylate Synthase (TS) (EC 220.127.116.11) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Host Species: Mouse
Clone: TS 106
Species Reactivity: Human. Others not known.
Epitope: Not determined
Immunogen: Recombinant human TS enzyme
Molecular Weight: 36kDa
Positive Control: 5-FU-resistant cell cancer lines or colon CA
Cellular Localization: Nuclear and cytoplasmic
- Western Blotting
- Immunoprecipitation (Native verified)
- Flow Cytometry
USA: RUO; Int'l: RUO
|Thymidylate Synthase Ab-1|
|Recombinant human TS enzyme|
|Flow Cytometry,Immunofluorescence,Immunoprecipitation,Western Blotting|