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Thermo Scientific™ Lab Vision™ Thymidylate Synthase Ab-1, Mouse Monoclonal Antibody


Provide accurate, reproducible results Thermo Scientific™ Thymidylate Synthase Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS471P1ABX

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Catalog No. MS471P1ABX

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Description & Specifications

Specifications

Antigen Thymidylate Synthase Ab-1
Applications Flow Cytometry
Applications Immunofluorescence
Applications Immunoprecipitation
Applications Western Blotting
Classification Monoclonal
Clone TS 106
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Host Species Mouse
Immunogen Recombinant human TS enzyme
Isotype IgG2a kappa
Quantity 100µL
Regulatory Status RUO
Research Discipline DNA Repair
Type Primary

Provide accurate, reproducible results Thermo Scientific™ Thymidylate Synthase Ab-1, Mouse Monoclonal Antibody.

Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Host Species: Mouse

Clone: TS 106

Isotype: IgG1/κ

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Recombinant human TS enzyme

Molecular Weight: 36kDa

Positive Control: 5-FU-resistant cell cancer lines or colon CA

Cellular Localization: Nuclear and cytoplasmic

Recommended for:

  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation (Native verified)
  • ELISA
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO