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Thermo Scientific™ Lab Vision™ Thymidylate Synthase Ab-1, Mouse Monoclonal Antibody

Provide accurate, reproducible results Thermo Scientific™ Thymidylate Synthase Ab-1, Mouse Monoclonal Antibody.

Manufacturer:  Thermo Scientific™ Lab Vision™ MS471P1ABX

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Catalog No. MS471P1ABX


 

Specifications

Description

Provide accurate, reproducible results Thermo Scientific™ Thymidylate Synthase Ab-1, Mouse Monoclonal Antibody.

Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Host Species: Mouse

Clone: TS 106

Isotype: IgG1/κ

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Recombinant human TS enzyme

Molecular Weight: 36kDa

Positive Control: 5-FU-resistant cell cancer lines or colon CA

Cellular Localization: Nuclear and cytoplasmic

Recommended for:

  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation (Native verified)
  • ELISA
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

Thymidylate Synthase Ab-1
Monoclonal
1mg/mL
Human
Murine
IgG2a kappa
RUO
Primary
Human
Flow Cytometry,Immunofluorescence,Immunoprecipitation,Western Blotting
TS 106
Unlabeled
Concentrated
Recombinant human TS enzyme
100μL
DNA Repair
Monoclonal