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Thermo Scientific™ Lab Vision™ Thrombospondin (TSP) Ab-3, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ Thrombospondin (TSP) Ab-3, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS420P1ABX

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Catalog No. MS420P1ABX

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Description & Specifications

Specifications

Antigen Thrombospondin (TSP) Ab-3
Applications Flow Cytometry
Applications Immunofluorescence
Applications Immunoprecipitation
Applications Western Blotting
Classification Monoclonal
Clone C6.7
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Bovine
Cross Reactivity Canine
Cross Reactivity Equine
Cross Reactivity Human
Cross Reactivity Porcine
Cross Reactivity Rat
Cross Reactivity Sheep
Format Concentrated
Host Species Mouse
Immunogen Ca2plus-replete, native purified human TSP from supernatant of thrombin-activated platelets
Isotype IgG1
Quantity 100µL
Regulatory Status RUO
Research Discipline Angiogenesis
Type Primary

Provide accurate, reproducible results with the Thermo Scientific™ Thrombospondin (TSP) Ab-3, Mouse Monoclonal Antibody.

Thrombospondin is a protein from platelet a-granules. It is made up of three identical subunits bound by interchain disulfides. It is secreted at sites of platelet activation and aggregation and is involved in the processes of chemotaxis, adhesion, proliferation and differentiation of leukocytes, fibroblasts, smooth muscle and endothelial cells.

Host Species: Mouse

Clone: C6.7

Isotype: IgG1

Species Reactivity: Human, Cow, Pig, Horse, Dog, Sheep and Rat. Others not known.

Epitope: Platelet- or cell-binding domain at the extreme C-terminus of TSP

Immunogen: Ca2+-replete, native purified human TSP from supernatant of thrombin-activated platelets

Molecular Weight: ∽450kDa (Nonreduced)

Cellular Localization: Secretory granules, Golgi complex, endoplasmic reticulum, extracellular matrix Ab-3 shows no cross-reaction with fibronectin, fibrinogen, and von Willebrand factor. It blocks TSP-mediated agglutination of fixed RBCs. It shows no effect on TSP-mediated agglutination of fixed, activated platelets. It inhibits both thrombin- and A23187-induced aggregation of washed, live (not fixed) platelets without affecting the secretion of serotonin. It inhibits adhesion of melanoma G361 cells to TSP. It blocks binding of C-terminal domain to Integrin-Associated Protein (IAP)/CD47.

Recommended for:

  • Immunohistochemistry (Not suitable)
  • Western Blotting (Nonreduced only)
  • Immunofluorescence
  • Immunoprecipitation (Native verified)
  • Electron Microscopy
  • Flow Cytometry
  • Blocks Binding of TSP-1 to IAP/CD47

Note:

USA: RUO; Int'l: RUO