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Alfa Aesar™ Thiostrepton, Streptomyces laurentii, 90+%

Natural cyclic oligopeptide antibiotic

$265.24 - $1,087.19

Chemical Identifiers

CAS 1393-48-2
Molecular Formula C72H85N19O18S5
Molecular Weight (g/mol) 1664.887
MDL Number MFCD00135828
InChI Key NSFFHOGKXHRQEW-HBCYXZPESA-N
Synonym Bryamycin; Thiactin
PubChem CID 122173112
SMILES CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)C(=CC)NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
AAJ6233203 View Documents Alfa Aesar™
J6233203
1g Each for $265.24
 
AAJ6233206 View Documents Alfa Aesar™
J6233206
5g Each for $1,087.19
 
Description

Description

Applications
Thiostrepton exhibits antibiotic activity through blockade of ribosome turnover after an elongation step in protein synthesis by inhibiting both the dissociation of elongation factor G (EF-G) from the ribosome and the release of inorganic phosphate from EF-G following GTP hydrolysis. Thiostrepton is also described to show efficacy against cancer cell growth through downregulation of the forkhead box M1 (FOXM1) transcription factor, commonly overexpressed in many malignancies. Thiostrepton is an inhibitor of FOXM1. Thiostrepton has been used as a selectable marker for recombinant Streptomyces cultures.

Solubility
Soluble in DMSO or chloroform

Notes
Store at -20°C. Incompatible with oxidizing agents. Protect from heat.
Specifications

Chemical Identifiers

1393-48-2
1664.887
NSFFHOGKXHRQEW-HBCYXZPESA-N
122173112
C72H85N19O18S5
MFCD00135828
Bryamycin; Thiactin
CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)C(=CC)NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C

Specifications

1393-48-2
MFCD00135828
Bryamycin; Thiactin
NSFFHOGKXHRQEW-HBCYXZPESA-N
1664.887
1664.89
≥90%
1g
C72H85N19O18S5
14,9364
Soluble in DMSO or chloroform
CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)C(=CC)NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C
122173112
Powder
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Thiostrepton, Streptomyces laurentii
Safety and Handling

Safety and Handling

RTECSNumber : XN6300100

Recommended Storage : −30° to −10°C