Invitrogen™ Human Activin A Recombinant Protein

Description

Inhibin Beta A Chain (human) Recombinant Protein, RP-75635, from Invitrogen.

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive. RP-75635 contains a purified 116 amino acid fragment (aa311-426) corresponding to the mature Inhibin beta A chain protein with an N-terminal hexahistidine tag. RP-75635 may be used as a positive control in Western blot assays. This protein has a molecular weight of ∽17.47 kDa.