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Tetraethyl methylenediphosphonate, 98+%, Thermo Scientific Chemicals
Supplier: Thermo Scientific Chemicals A1453206
Description
Tetraethyl methylidenediphosphonate is used in the synthesis of tetrazoloquinoline-based mono- and bisphosphonate esters. It acts as an intermediate for the synthesis of bisphosphonate and bisphosphonic acid derivatives with anticancer and antischistosomal activity. It is also used as a reactant for synthesis of dual substrate-site inhibitors of 3-deoxy-D-arabino-heputosonate 7-phosphate synthase and alpha-amino acid derivatives containing gem-biophosphonates, Lycopene through Wittig-Horner reaction. It is also used as a precursor for the preparation of dendritic polyglycerol anions.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsTetraethyl methylidenediphosphonate is used in the synthesis of tetrazoloquinoline-based mono- and bisphosphonate esters. It acts as an intermediate for the synthesis of bisphosphonate and bisphosphonic acid derivatives with anticancer and antischistosomal activity. It is also used as a reactant for synthesis of dual substrate-site inhibitors of 3-deoxy-D-arabino-heputosonate 7-phosphate synthase and alpha-amino acid derivatives containing gem-biophosphonates, Lycopene through Wittig-Horner reaction. It is also used as a precursor for the preparation of dendritic polyglycerol anions.
Solubility
Slightly miscible with water.
Notes
Incompatible with strong oxidizing agents.
Specifications
| Tetraethyl methylenediphosphonate | |
| 1.162 | |
| >110°C (230°F) | |
| 1.44 | |
| 5 g | |
| tetraethyl methylenediphosphonate, tetraethyl methanediphosphonate, tetraethyl diphosphonomethane, methylenebis diethylphosphonate, tetraethyl methylenebisphosphonate, phosphonic acid, methylenebis-, tetraethyl ester, methylenebis diethoxyphosphine oxide, methylenebisphosphonic acid, tetraethyl ester, phosphonic acid, methylenedi-, tetraethyl ester, methylenedi phosphonic acid tetraethyl ester | |
| STJWVOQLJPNAQL-UHFFFAOYSA-N | |
| diethyl [(diethoxyphosphoryl)methyl]phosphonate | |
| 15455 | |
| ≥98% |
| 1660-94-2 | |
| 151°C to 153°C (1.2 mmHg) | |
| C9H22O6P2 | |
| MFCD00039887 | |
| 1813241 | |
| Slightly miscible with water. | |
| CCOP(=O)(CP(=O)(OCC)OCC)OCC | |
| 288.22 | |
| 288.22 |
Chemical Identifiers
| 1660-94-2 | |
| 288.22 | |
| STJWVOQLJPNAQL-UHFFFAOYSA-N | |
| 15455 |
| C9H22O6P2 | |
| MFCD00039887 | |
| tetraethyl methylenediphosphonate, tetraethyl methanediphosphonate, tetraethyl diphosphonomethane, methylenebis diethylphosphonate, tetraethyl methylenebisphosphonate, phosphonic acid, methylenebis-, tetraethyl ester, methylenebis diethoxyphosphine oxide, methylenebisphosphonic acid, tetraethyl ester, phosphonic acid, methylenedi-, tetraethyl ester, methylenedi phosphonic acid tetraethyl ester | |
| CCOP(=O)(CP(=O)(OCC)OCC)OCC |
Safety and Handling
GHS H Statement
H315-H319
Causes skin irritation.
Causes serious eye irritation.
P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
H315-H319-H335
EINECSNumber : 216-764-5
RTECSNumber : SZ9150000
TSCA : Yes
Recommended Storage : Ambient temperatures
RUO – Research Use Only