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TCL1 Mouse anti-Human, Clone: eBio1-21 (1-21), eBioscience™

Mouse Monoclonal Antibody

$129.05 - $375.55

Specifications

Antigen TCL1
Clone eBio1-21 (1-21)
Host Species Mouse
Gene Alias T Cell Leukemia/Lymphoma 1, TCL-1
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5013514

 
affymetrix
14669980
25μg Each for $129.05

5013515

 
affymetrix
14669982
100μg Each for $375.55
Description & Specifications

Specifications

Antigen TCL1
Clone eBio1-21 (1-21)
Host Species Mouse
Gene Alias T Cell Leukemia/Lymphoma 1, TCL-1
Species Reactivity Human
Applications Flow Cytometry (Intracellular Staining)
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The eBio1-21 antibody reacts with human T cell leukemia/lymphoma 1 (TCL1), a 14kDa proto-oncogene product with a suggested role in intracellular regulation of T cell signalling. TCL1 was identified as the oncogene located at the 14q32.1 chromosome breakpoint region in T-cell prolymphocytic leukemia (T-PLL). In T-PLL, TCL1 is overexpressed as a result of an inversion or a reciprocal translocation, by juxtaposition to the T-cell receptor promoter/enhancer elements. TCL1 binds to the pleckstrin homology domain of Akt (protein kinase B) family proteins, which facilitates Akt dimerization and activity. By increasing Akt activity TCL1 may enhance the serine/threonine phosphorylation of major Akt signaling substrates, such as Ikk complex, mTOR, BAD, p70S6 kinase, FOXO transcription factors, and GSK3β. These substrates regulate cellular differentiation, growth, survival, and metabolism.

Besides its tumorigenic role in T-PLL, TCL1 is normally expressed in the CD3-CD4-CD8- subset of thymic precursors in the T cell lineage, the plasmacytoid subset of dendritic cells, stimulated (not resting) mature T cells, and B cells up to the germinal center stage of maturation. TCL1 is inappropriately expressed by chromosome rearrangements that lead to pre-malignant clonal T cell expansions and mature T cell tumors. TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia (CLL).