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Tamoxifen, 98%, Thermo Scientific Chemicals
Tamoxifen (citofen, CAS # 10540-29-1) is an antineoplastic agent that has its effect through the estrogen receptors.
Supplier: Thermo Scientific Chemicals J6350903
Description
Inhibitor of protein kinase C and induces apoptosis in cancer cells. It is utilized in the study on lipopolysaccharide (LPS)-induced microglial activation to know its effect.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Tamoxifen is a tertiary aminobenzene that acts by competitively binding and antagonizing estrogen receptors to reduce DNA synthesis
- When estradiol cannot bind estrogen receptors, the DNA response element is not activated
- Tamoxifen upregulates the production of TGFb and slows tumor growth
- Tamoxifen inhibits the production of IGF-1, a stimulator of tumor growth
Application
- Tamoxifen may be useful in the study of tumorigenesis, growth, and inflammation
- It is suitable for in vitro experiments
Specifications
| Tamoxifen | |
| White | |
| MFCD00010454 | |
| 14,9048 | |
| Insoluble in water; Soluble in methanol,ethanol,propanol or propylene glycol;Soluble in dimethyl sulfoxide,dichloromethane and ethanol; Insoluble in water. | |
| CC\C(=C(/C1=CC=CC=C1)C1=CC=C(OCCN(C)C)C=C1)C1=CC=CC=C1 | |
| 371.52 | |
| CHEBI:41774 | |
| 98% |
| 10540-29-1 | |
| C26H29NO | |
| 1 g | |
| tamoxifen, trans-tamoxifen, crisafeno, soltamox, tamoxifene, diemon, tamoxifeno, tamoxifenum, citofen, istubol | |
| NKANXQFJJICGDU-QPLCGJKRSA-N | |
| (2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethyl)dimethylamine | |
| 2733526 | |
| 371.52 | |
| Powder |
Chemical Identifiers
| 10540-29-1 | |
| 371.52 | |
| NKANXQFJJICGDU-QPLCGJKRSA-N | |
| 2733526 | |
| (2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethyl)dimethylamine |
| C26H29NO | |
| MFCD00010454 | |
| tamoxifen, trans-tamoxifen, crisafeno, soltamox, tamoxifene, diemon, tamoxifeno, tamoxifenum, citofen, istubol | |
| CHEBI:41774 | |
| CC\C(=C(/C1=CC=CC=C1)C1=CC=C(OCCN(C)C)C=C1)C1=CC=CC=C1 |
Safety and Handling
GHS H Statement
H350-H360-H362
May cause cancer.
May damage fertility or the unborn child.
May cause harm to breast-fed children.
P201-P202-P260-P263-P264b-P270-P281-P301+P312-P308+P313-P330-P501c
H302-H350-H360FD-H362
EINECSNumber : 234-118-0
RTECSNumber : KR5919600
TSCA : No
Recommended Storage : Store at -20°C
RUO – Research Use Only