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Alfa Aesar™ Tamibarotene

A retinoic acid receptor → (RAR→) agonist

$192.77 - $791.11

Chemical Identifiers

CAS 94497-51-5
Molecular Formula C22H25NO3
Molecular Weight (g/mol) 351.446
MDL Number MFCD00866188
InChI Key MUTNCGKQJGXKEM-UHFFFAOYSA-N
Synonym tamibarotene, retinobenzoic acid, 4-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl carbamoyl benzoic acid, amnolake, tamibaro, amnoid, unii-08v52gz3h9, 4-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl carbamoyl benzoic acid, 4-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl carbamoyl benzoic acid, chembl25202
PubChem CID 108143
ChEBI CHEBI:32181
IUPAC Name 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid
SMILES CC1(CCC(C2=C1C=CC(=C2)NC(=O)C3=CC=C(C=C3)C(=O)O)(C)C)C
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
AAJ64028MA View Documents Alfa Aesar™
J64028MA
10mg Each for $192.77
 
AAJ64028MF View Documents Alfa Aesar™
J64028MF
50mg Each for $791.11
 
Description

Description

Applications
Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo. It has also been shown to suppress the growth of other myeloid and lymphoid malignant cells.

Solubility
Soluble to 50 mM in DMSO

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.
Specifications

Chemical Identifiers

94497-51-5
351.446
MUTNCGKQJGXKEM-UHFFFAOYSA-N
108143
4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid
C22H25NO3
MFCD00866188
tamibarotene, retinobenzoic acid, 4-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl carbamoyl benzoic acid, amnolake, tamibaro, amnoid, unii-08v52gz3h9, 4-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl carbamoyl benzoic acid, 4-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl carbamoyl benzoic acid, chembl25202
CHEBI:32181
CC1(CCC(C2=C1C=CC(=C2)NC(=O)C3=CC=C(C=C3)C(=O)O)(C)C)C

Specifications

White
94497-51-5
MFCD00866188
tamibarotene, retinobenzoic acid, 4-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl carbamoyl benzoic acid, amnolake, tamibaro, amnoid, unii-08v52gz3h9, 4-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl carbamoyl benzoic acid, 4-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl carbamoyl benzoic acid, chembl25202
MUTNCGKQJGXKEM-UHFFFAOYSA-N
4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid
108143
351.44
Tamibarotene
10mg
C22H25NO3
14,9047
Soluble to 50 mM in DMSO
CC1(CCC(C2=C1C=CC(=C2)NC(=O)C3=CC=C(C=C3)C(=O)O)(C)C)C
351.446
CHEBI:32181
Solid
Safety and Handling

Safety and Handling

RTECSNumber : DH6940000