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T-bet Mouse, Clone: 39D, eBioscience™

Mouse Monoclonal Antibody

$129.05 - $375.55

Specifications

Antigen T-bet
Clone 3-9D)
Host Species Mouse
Gene Alias Tbet, Th1-specific T box transcription factor, T-box expressed in T cells
Species Reactivity Human, Mouse, Rat
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122695

 
affymetrix
14582482
100μg Each for $375.55

5013187

 
affymetrix
14-5824-80
25μg Each for $129.05
Description & Specifications

Specifications

Antigen T-bet
Clone 3-9D)
Host Species Mouse
Gene Alias Tbet, Th1-specific T box transcription factor, T-box expressed in T cells
Species Reactivity Human, Mouse, Rat
Applications Immunoprecipitation
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The eBio39D monoclonal antibody reacts with mouse, rat and human T-bet. T-bet is a Th1-specific T-box transcription factor critical to the development of the Th1 CD4+ T cell lineage. This is known based on the observations that T-Bet deficient mice have impaired Th1 cell development, and that ectopic expression of T-Bet results in development skewed to the Th1 lineage. T-Bet expression is induced by the Th1 cytokine IFN-γ, and T-Bet also regulates the expression of IFN-γ, likely, at least in part, through the modification of DNA accessibility and histone remodeling. In addition to IFN-γ, T-Bet is also known to regulate the expression of IL-12Rβ and IL-2. Moreover, T-Bet plays a role in class-switch recombination in B-cells.