T-bet Mouse anti-Human, Mouse, Rhesus Monkey, PerCP-Cyanine5.5, Clone: eBio4B10 (4B10), eBioscience™
Mouse Monoclonal Antibody
Manufacturer: Life Technologies LS45582582
Description: The eBio4B10 monoclonal antibody reacts with mouse and human T-bet. T-bet is a Th1-specific T-box transcription factor critical to the development of the Th1 CD4+ T cell lineage. This is known based on the observations that T-Bet deficient miFor intracellular staining with the eBio4B10 monoclonal antibody, it is recommended to use the Foxp3/Transcription Factor Staining Buffer Set (cat. 00-5523) and protocol. Please refer to Best Protocols; Protocol B: One step protocol for intracellular (nuclear) proteins). Excitation: 488 nm; Emission: 695 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered. T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.
|PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2|
|T-PET, T-bet, TBET, TBLYM, T-box expressed in T cells; T-box protein 21; T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; transcription factor TBLYM|
|Human, Mouse, Rhesus Monkey|
|eBio4B10 (4B10), 4-B10)|
|4° C, store in dark, DO NOT FREEZE!|
|30009, 57765, 694044|
For Research Use Only.