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T-bet Mouse anti-Human, Mouse, PE-Cy7, Clone: 4B10, eBioscience™

Mouse Monoclonal Antibody

$216.05 - $564.05

Specifications

Antigen T-bet
Clone 4-B10)
Host Species Mouse
Gene Alias Th1-specific T box transcription factor, T-box expressed in T cells
Species Reactivity Human, Mouse, Rhesus Ma
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

50245751

 
affymetrix
25582580
25μg Each for $216.05

50245752

 
affymetrix
25582582
100μg Each for $564.05
Description & Specifications

Specifications

Antigen T-bet
Clone 4-B10)
Host Species Mouse
Gene Alias Th1-specific T box transcription factor, T-box expressed in T cells
Species Reactivity Human, Mouse, Rhesus Ma
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate PE-Cy7
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The eBio4B10 monoclonal antibody reacts with mouse and human T-bet. T-bet is a Th1-specific T-box transcription factor critical to the development of the Th1 CD4+ T cell lineage. This is known based on the observations that T-Bet deficient mice have impaired Th1 cell development, and that ectopic expression of T-Bet results in development skewed to the Th1 lineage. T-Bet expression is induced by the Th1 cytokine IFN gamma, and T-Bet also regulates the expression of IFN gamma, likely, at least in part, through the modification of DNA accessibility and histone remodeling. In addition to IFN gamma, T-Bet is also known to regulate the expression of IL-12R beta and IL-2. Moreover, T-Bet plays a role in class-switch recombination in B-cells.