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T-bet, PE, clone: eBio4B10 (4B10), eBioscience™

Mouse Monoclonal Antibody

Manufacturer:  Life Technologies LS12582582

 View more versions of this product

Catalog No. 501129387



Description

Description

T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.

It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. For intracellular staining with the eBio4B10 monoclonal antibody, it is recommended to use the eBioscience Foxp3/Transcription Factor Staining Buffer Set (cat. 00-5523) and protocol. Please refer to Best Protocols: Protocol B: One step protocol for intracellular (nuclear) proteins). Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered. T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.
Specifications

Specifications

T-bet
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Q9JKD8, Q9UL17
T-PET, T-bet, TBET, TBLYM, T-box expressed in T cells; T-box protein 21; T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; transcription factor TBLYM
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human, Mouse, Rhesus Monkey
Flow Cytometry
eBio4B10 (4B10), 4-B10)
PE
TBX21
Liquid
TBX21
IgG1, kappa
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
30009, 57765, 694044
Documents

For Research Use Only.