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T-bet, eFluor 660, clone: eBio4B10 (4B10), eBioscience™

Mouse Monoclonal Antibody

Manufacturer:  Life Technologies LS50582582

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Catalog No. 501129442



Description

Description

T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.

It is recommended to use the Foxp3/Transcription Factor Staining Buffer Set (cat. 00-5523) and protocol. Refer to Best Protocols for Staining Protocol (Protocol B: One step protocol for intracellular (nuclear) proteins) eFluor® 660 is a replacement for Alexa Fluor® 647. eFluor® 660 emits at 659 nm and is excited with the red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome. Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered. T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.
Specifications

Specifications

T-bet
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Q9JKD8, Q9UL17
T-PET, T-bet, TBET, TBLYM, T-box expressed in T cells; T-box protein 21; T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; transcription factor TBLYM
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human, Mouse, Rhesus Monkey
Flow Cytometry
eBio4B10 (4B10), 4-B10)
eFluor® 660
TBX21
Liquid
TBX21
IgG1, kappa
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
30009, 57765, 694044
Documents

For Research Use Only.