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T-bet Mouse anti-Human, Mouse, Clone: 4B10, eBioscience™

Mouse Monoclonal Antibody

$143.55 - $303.05

Specifications

Antigen T-bet
Clone 4-B10)
Host Species Murine
Gene Alias Th1-specific T box transcription factor, T-box expressed in T cells
Species Reactivity Human, Mouse, Rhesus Ma
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5013189 Life Technologies
LS14582580
25μg Each for $143.55
5013190 Life Technologies
LS14582582
100μg Each for $303.05
Specifications

Description

The eBio4B10 monoclonal antibody reacts with mouse and human T-bet. T-bet is a Th1-specific T-box transcription factor critical to the development of the Th1 CD4+ T cell lineage. This is known based on the observations that T-Bet deficient mice have impaired Th1 cell development, and that ectopic expression of T-Bet results in development skewed to the Th1 lineage. T-Bet expression is induced by the Th1 cytokine IFN gamma, and T-Bet also regulates the expression of IFN gamma, likely, at least in part, through the modification of DNA accessibility and histone remodeling. In addition to IFN gamma, T-Bet is also known to regulate the expression of IL-12R beta and IL-2. Moreover, T-Bet plays a role in class-switch recombination in B-cells.
Description & Specifications

Specifications

T-bet
Murine
Human, Mouse, Rhesus Ma
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
4-B10)
Th1-specific T box transcription factor, T-box expressed in T cells
Immunohistochemistry,Immunohistochemistry (Formalin/Paraffin),Immunoprecipitation,Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL