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Survivin (BIRC5) Mouse anti-Human, Clone: STLALYV, eBioscience™

Mouse Monoclonal Antibody

$174.24 - $389.40

Specifications

Antigen Survivin (BIRC5)
Clone STLALYV
Host Species Murine
Gene Alias Birc5
Species Reactivity Human
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122774 Life Technologies
LS14917680
25μg Each for $174.24
501122775 Life Technologies
LS14917682
100μg Each for $389.40
Specifications

Description

This STLALYV monoclonal antibody recognizes human survivin (also known as Birc5). Survivin is a member of the inhibitor of apoptosis (IAP) family that also includes XIAP, c-IAP1, c-IAP2, and NAIP. Survivin functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis. Survivin also plays a critical role in mitosis and cytokinesis where it is expressed only during G2/M and localizes to the mitotic spindle and is found at the cleavage furrow/midplate. Thus, survivin is highly expressed in tumors and in fetal tissue, but is absent in terminally-differentiated cells and non-proliferating cells. Deletion of survivin in developing thymocytes as well as in mature T cells showed that survivin is critical for cell division in lymphoid cells but not for inhibition of survival; the same is true for B lymphocytes.
Description & Specifications

Specifications

Survivin (BIRC5)
Murine
Human
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
STLALYV
Birc5
Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin),Microscopy
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL