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Survivin (BIRC5) Mouse anti-Human, Alexa Fluor 488, Clone: STLALYV, eBioscience™

Mouse Monoclonal Antibody

$227.04 - $539.88

Specifications

Antigen Survivin (BIRC5)
Clone STLALYV
Host Species Murine
Gene Alias Birc5
Species Reactivity Human
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501124618 Life Technologies
LS53917680
25μg Each for $227.04
501124619 Life Technologies
LS53917682
100μg Each for $539.88
Specifications

Description

This STLALYV monoclonal antibody recognizes human survivin (also known as Birc5). Survivin is a member of the inhibitor of apoptosis (IAP) family that also includes XIAP, c-IAP1, c-IAP2, and NAIP. Survivin functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis. Survivin also plays a critical role in mitosis and cytokinesis where it is expressed only during G2/M and localizes to the mitotic spindle and is found at the cleavage furrow/midplate. Thus, survivin is highly expressed in tumors and in fetal tissue, but is absent in terminally-differentiated cells and non-proliferating cells. Deletion of survivin in developing thymocytes as well as in mature T cells showed that survivin is critical for cell division in lymphoid cells but not for inhibition of survival; the same is true for B lymphocytes.
Description & Specifications

Specifications

Survivin (BIRC5)
Murine
Human
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
STLALYV
Birc5
Immunocytochemistry,Microscopy
Alexa Fluor 488
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
0.5mg/mL