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Thermo Scientific™ Lab Vision™ Survivin Ab-6, Rabbit Polyclonal Antibody

Provide accurate, reproducible results with the Thermo Scientific™ Survivin Ab-6, Rabbit Polyclonal Antibody.

$260.63 - $1,285.53

Specifications

Antigen Survivin Ab-6
Concentration 1mg/mL
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Conjugate Unlabeled
View More Specs
Products
Catalog Number Mfr. No. Formulation Quantity Price Quantity    

RB1629P

 
thermo scientific™ lab vision™
RB-1629-P
Purified Ab with BSA and Azide 1mL Each for $1,206.92

RB1629P0

 
thermo scientific™ lab vision™
RB-1629-P0
Purified Ab with BSA and Azide 100µL Each for $260.63

RB1629P1

 
thermo scientific™ lab vision™
RB-1629-P1
Purified Ab with BSA and Azide 500µL Each for $714.90

RB1629P1ABX

 
thermo scientific™ lab vision™
RB1629P1ABX
Ab without BSA/Azide (Frozen) 500µL Each for $802.27

RB1629PABX

 
thermo scientific™ lab vision™
RB1629PABX
Ab without BSA/Azide (Frozen) 1mL Each for $1,285.53
Description & Specifications

Specifications

Antigen Survivin Ab-6
Concentration 1mg/mL
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Host Species Rabbit
Regulatory Status RUO
Research Discipline Apoptosis
Type Primary
Immunogen A synthetic peptide derived from the C-terminus of survivin
Isotype IgG

Provide accurate, reproducible results with the Thermo Scientific™ Survivin Ab-6, Rabbit Polyclonal Antibody.

Survivin, a new inhibitor of apoptosis (IAP) protein, is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It indicates that survivin may counteract a default induction of apoptosis in G2/M phase. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favour aberrant progression of transformed cells through mitosis.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human and Mouse. Others not tested.

Epitope: C-terminal

Immunogen: A synthetic peptide derived from the C-terminus of survivin

Molecular Weight: 16.5kDa

Positive Control: Stomach

Cellular Localization: Cytoplasmic and Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)

Note:

USA: RUO; Int'l: RUO