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Thermo Scientific™ Lab Vision™ Survivin Ab-6, Rabbit Polyclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ Survivin Ab-6, Rabbit Polyclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  RB1629P1ABX

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Catalog No. RB1629P1ABX

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Description & Specifications

Specifications

Antigen Survivin Ab-6
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Formulation Ab without BSA/Azide (Frozen)
Host Species Rabbit
Immunogen A synthetic peptide derived from the C-terminus of survivin
Isotype IgG
Quantity 500µL
Regulatory Status RUO
Research Discipline Apoptosis
Type Primary

Provide accurate, reproducible results with the Thermo Scientific™ Survivin Ab-6, Rabbit Polyclonal Antibody.

Survivin, a new inhibitor of apoptosis (IAP) protein, is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It indicates that survivin may counteract a default induction of apoptosis in G2/M phase. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favour aberrant progression of transformed cells through mitosis.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human and Mouse. Others not tested.

Epitope: C-terminal

Immunogen: A synthetic peptide derived from the C-terminus of survivin

Molecular Weight: 16.5kDa

Positive Control: Stomach

Cellular Localization: Cytoplasmic and Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)

Note:

USA: RUO; Int'l: RUO