Thermo Scientific™ Lab Vision™ Survivin Ab-6, Rabbit Polyclonal Antibody
Provide accurate, reproducible results with the Thermo Scientific™ Survivin Ab-6, Rabbit Polyclonal Antibody.
Manufacturer: Thermo Scientific™ Lab Vision™ RB1629P1ABX
Provide accurate, reproducible results with the Thermo Scientific™ Survivin Ab-6, Rabbit Polyclonal Antibody.Survivin, a new inhibitor of apoptosis (IAP) protein, is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It indicates that survivin may counteract a default induction of apoptosis in G2/M phase. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favour aberrant progression of transformed cells through mitosis.
Host Species: Rabbit
Species Reactivity: Human and Mouse. Others not tested.
Immunogen: A synthetic peptide derived from the C-terminus of survivin
Molecular Weight: 16.5kDa
Positive Control: Stomach
Cellular Localization: Cytoplasmic and Nuclear
- Immunohistochemistry (Formalin/paraffin)
USA: RUO; Int'l: RUO
|Ab without BSA/Azide (Frozen)|
|A synthetic peptide derived from the C-terminus of survivin|