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Thermo Scientific™ Survivin Ab-1, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ Survivin Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™  MS1201PABX

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Catalog No. MS1201PABX

  • / Each
 

Description & Specifications

Specifications

Antigen Survivin Ab-1
Applications Immunofluorescence
Classification Monoclonal
Clone 8E2
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Rat
Format Concentrated
Host Species Mouse
Immunogen Full length recombinant human survivin protein
Isotype IgG2a kappa
Quantity 200µL
Regulatory Status RUO
Research Discipline Apoptosis
Type Primary

Provide accurate, reproducible results with the Thermo Scientific™ Survivin Ab-1, Mouse Monoclonal Antibody.

Research Areas: Apoptosis; Survivin, a new inhibitor of apoptosis (IAP) protein, is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It indicates that survivin may counteract a default induction of apoptosis in G2/M phase. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favour aberrant progression of transformed cells through mitosis.

Host Species: Mouse

Clone: 8E2

Isotype: IgG1/κ

Species Reactivity: Human and Rat. Others not known.

Epitope: aa 1-99

Immunogen: Full-length recombinant human survivin protein

Molecular Weight: 16.5kDa

Positive Control: HeLa cells

Cellular Localization: Cytoplasmic and nuclear

Recommended for:

  • Immunohistochemistry (Not suitable)
  • Western Blotting (Not suitable)
  • Immunofluorescence

Note:

USA: RUO; Int'l: RUO