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Thermo Scientific™ Survivin Ab-1, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ Survivin Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™  MS1201P1ABX

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Catalog No. MS1201P1ABX

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Description & Specifications

Specifications

Quantity 100µL
Clone 8E2
Cross Reactivity Human
Cross Reactivity Rat
Host Species Mouse
Immunogen Full length recombinant human survivin protein
Isotype IgG2a kappa
Antigen Survivin Ab-1
Format Concentrated
Applications Immunofluorescence
Regulatory Status RUO
Research Discipline Apoptosis
Type Primary
Concentration 1mg/mL
Classification Monoclonal
Conjugate Unlabeled

Provide accurate, reproducible results with the Thermo Scientific™ Survivin Ab-1, Mouse Monoclonal Antibody.

Research Areas: Apoptosis; Survivin, a new inhibitor of apoptosis (IAP) protein, is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It indicates that survivin may counteract a default induction of apoptosis in G2/M phase. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favour aberrant progression of transformed cells through mitosis.

Host Species: Mouse

Clone: 8E2

Isotype: IgG1/κ

Species Reactivity: Human and Rat. Others not known.

Epitope: aa 1-99

Immunogen: Full-length recombinant human survivin protein

Molecular Weight: 16.5kDa

Positive Control: HeLa cells

Cellular Localization: Cytoplasmic and nuclear

Recommended for:

  • Immunohistochemistry (Not suitable)
  • Western Blotting (Not suitable)
  • Immunofluorescence

Note:

USA: RUO; Int'l: RUO