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Thermo Scientific™ Lab Vision™ Surfactant Protein B (Precursor) Ab-1, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ Surfactant Protein B (Precursor) Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS704P1ABX

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Catalog No. MS704P1ABX

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Description & Specifications

Specifications

Antigen Surfactant Protein B (Precursor) Ab-1
Applications Immunofluorescence
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone SPB01; same as 1-2-A5-9
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Rat
Format Concentrated
Formulation Ab without BSA/Azide (Frozen)
Host Species Murine
Immunogen Recombinant pro-surfactant protein B
Isotype IgG2a kappa
Quantity 100μL
Regulatory Status RUO
Research Discipline Cancer and Tumor Biology
Type Primary
Monoclonal or Polyclonal Monoclonal
Target Species Human
Target Species Rat

Provide accurate, reproducible results with the Thermo Scientific™ Surfactant Protein B (Precursor) Ab-1, Mouse Monoclonal Antibody.

Pulmonary surfactant is a complex mixture of phospholipids and proteins that is secreted from type II cells in alveoli and reduces the surface tension at the alveolar air-liquid interface, providing alveolar stability necessary for normal ventillation. Four distinct proteins isolated from pulmonary surfactant are termed surfactant proteins A, B, C, and D. SP-A (28-36kDa) and SP-D (43kDa) are collagenous carbohydrate-binding proteins, whereas SP-B (8-9kDa) and SP-C (4kDa) are non-collagenous hydrophobic proteins. SP-B is expressed in pulmonary adenocarcinomas with acinar, papillary, bronchioloalveolar, and solid growth patterns. Squamous cell and large cell carcinomas of the lung and nonpulmonary adenocarcinomas do not express SP-B. ProSP-B is glycosylated in the Golgi apparatus and undergoes carboxy- and amino-terminal proteolysis by a cathepsin D-like protease.

Host Species: Mouse

Clone: SPB01; same as 1-2-A5-9

Isotype: IgG2a/κ

Species Reactivity: Human and Rat. Others not known.

Epitope: Not determined

Immunogen: Recombinant prosurfactant protein B

Molecular Weight: 42-46kDa

Positive Control: Lung adenocarcinoma

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Immunofluorescence

Note:

USA: RUO; Int'l: RUO