Thermo Scientific™ Lab Vision™ Surfactant Protein B (Precursor) Ab-1, Mouse Monoclonal Antibody
Provide accurate, reproducible results with the Thermo Scientific™ Surfactant Protein B (Precursor) Ab-1, Mouse Monoclonal Antibody.
Manufacturer: Thermo Scientific™ Lab Vision™ MS704P1ABX
Provide accurate, reproducible results with the Thermo Scientific™ Surfactant Protein B (Precursor) Ab-1, Mouse Monoclonal Antibody.Pulmonary surfactant is a complex mixture of phospholipids and proteins that is secreted from type II cells in alveoli and reduces the surface tension at the alveolar air-liquid interface, providing alveolar stability necessary for normal ventillation. Four distinct proteins isolated from pulmonary surfactant are termed surfactant proteins A, B, C, and D. SP-A (28-36kDa) and SP-D (43kDa) are collagenous carbohydrate-binding proteins, whereas SP-B (8-9kDa) and SP-C (4kDa) are non-collagenous hydrophobic proteins. SP-B is expressed in pulmonary adenocarcinomas with acinar, papillary, bronchioloalveolar, and solid growth patterns. Squamous cell and large cell carcinomas of the lung and nonpulmonary adenocarcinomas do not express SP-B. ProSP-B is glycosylated in the Golgi apparatus and undergoes carboxy- and amino-terminal proteolysis by a cathepsin D-like protease.
Host Species: Mouse
Clone: SPB01; same as 1-2-A5-9
Species Reactivity: Human and Rat. Others not known.
Epitope: Not determined
Immunogen: Recombinant prosurfactant protein B
Molecular Weight: 42-46kDa
Positive Control: Lung adenocarcinoma
Cellular Localization: Cytoplasmic
- Immunohistochemistry (Formalin/paraffin)
USA: RUO; Int'l: RUO
|Surfactant Protein B (Precursor) Ab-1|
|Ab without BSA/Azide (Frozen)|
|Recombinant pro-surfactant protein B|
|Cancer and Tumor Biology|
|SPB01; same as 1-2-A5-9|