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SSEA-5 Mouse anti-Human, Clone: 8E11-SSEA5, eBioscience™

Mouse Monoclonal Antibody

$129.05 - $317.55

Specifications

Antigen SSEA-5
Clone 8E11-SSEA5
Host Species Mouse
Gene Alias Stage-Specific Embryonic Antigen-5
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122738

 
affymetrix
14885782
100μg Each for $317.55

501122737

 
affymetrix
14885780
25μg Each for $129.05
Description & Specifications

Specifications

Antigen SSEA-5
Clone 8E11-SSEA5
Host Species Mouse
Gene Alias Stage-Specific Embryonic Antigen-5
Species Reactivity Human
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody 8E11-SSEA5 recognizes human stage-specific embryonic antigen-5 (SSEA-5), an H type-1 glycan. SSEA-5 belongs to the SSEA family of glycoproteins and is highly expressed on pluripotent human stem cells including embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. During embryonic development, SSEA-5 is expressed within the blastocyst on inner cell mass (ICM) cells that later give rise to ES cells. As ES and iPS cells differentiate, SSEA-5 expression is downregulated. The tumorigenic potential of contaminating stem cells in cell populations for transplantation is a hurdle to using this approach for disease therapy. The 8E11 antibody in combination with either CD9 and CD90 or CD50 and CD200 to sort populations has been shown to effectively separate teratoma-forming cells from stem cell-derived populations of differentiated cells.