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Thermo Scientific™ Lab Vision™ SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1, Mouse Monoclonal Antibody .

Manufacturer: thermo scientific™ lab vision™  MS1207PABX

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Catalog No. MS1207PABX

  • / Each
 

Description & Specifications

Specifications

Antigen SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1
Applications Immunoprecipitation
Applications Western Blotting
Classification Monoclonal
Clone 2A4
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Hamster
Cross Reactivity Human
Format Concentrated
Host Species Mouse
Immunogen Recombinant protein encoding N-terminal amino acids 301-407 (the bHLH/leucine zipper domain) of human SREBP-1
Isotype IgG2a kappa
Quantity 200µL
Regulatory Status RUO
Research Discipline Transcription Regulation
Type Primary

Provide accurate, reproducible results with the Thermo Scientific™ SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1, Mouse Monoclonal Antibody .

SREBP-1 and -2 are transcription factors which participate in the control of cholesterol homeostasis. SREBPs proteins, which are attached to the endoplasmic reticulum and nuclear envelope, are proteolytically cleaved and thus activated in response to conditions of low cellular sterol. Upon activation of SREBP-1 or -2, an ∽480-500 amino acid, N-terminal cleavage fragment of these proteins enters the nucleus and activates transcription of enzymes and other proteins required for cholesterol synthesis. SCA (SREBP-cleavage activity) and caspase-3 proteases cleave SREBPs. SREBP proteins containing point mutations at caspase-3 cleavage sites (Asp460 in SREBP-1 and Asp468 in SREBP-2) do not become cleaved following induction of apoptosis, suggesting that SREBPs may play some role in apoptotic processes.

Host Species: Mouse

Clone: 2A4

Isotype: IgG1/κ

Species Reactivity: Human and Hamster. Others not known.

Epitope: aa 301-407

Immunogen: Recombinant protein encoding N-terminal amino acids 301-407 (the bHLH/leucine zipper domain) of human SREBP-1

Molecular Weight: 125kDa (precursor) and 60-70kDa (cleaved)

Positive Control: HeLa and IMR5 cells

Cellular Localization: Cytoplasmic and nuclear

Recommended for:

  • Western Blotting
  • Immunoprecipitation (Not verified)

Note:

USA: RUO; Int'l: RUO