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Sox9 Mouse anti-Human, Mouse, Clone: GMPR9, eBioscience™

Mouse Monoclonal Antibody

$146.45 - $353.80

Specifications

Antigen Sox9
Clone GMPR9
Host Species Murine
Species Reactivity Human, Mouse
Applications Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin),Microscopy,Western Blot
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122843 Life Technologies
LS14976580
25μg Each for $146.45
501122844 Life Technologies
LS14976582
100μg Each for $353.80
Specifications

Description

This GMPR9 monoclonal antibody reacts with human and mouse Sox9, a member of the Sry HMG-box (Sox) gene family of transcription factors. Like Sry, Sox9 contains a high mobility group (HMG-box) DNA-binding domain. The Sox9 DNA-binding domain recognizes the sequence AGAACAATGG, and when bound to co-factors, functions to bend the DNA. This structural change is thought to be important for chromatin remodeling and the initiation of more broad transcriptional regulation of multiple genes. Sox9 is expressed in multiple tissue types during development and its activation of downstream targets is determined by interaction with tissue-specific co-factors. During development, Sox9 expression is important for cartilage formation (mesenchymal to chondrocyte), sex determination (testes formation), neural crest formation and retinal development. Sox9 plays a role in the differentiation of multiple cell types including glial, hair, cardiac, melanocytes, pancreatic, prostate, and intestinal epithelium. Sox9 regulates expression of the following family member genes sox5, sox6, and sox10, in addition to collagen type 2 alpha, collagen 9A1, CEACAM1, and snail2. Sox9 dysregulation is involved in craniofacial defects, cleft palate, sex reversal, and some types of cancer (melanoma, lung adenocarcinoma, and breast cancer). Sox9 has also been shown to be expressed in adult stem cells in the liver, pancreas and intestine.
Description & Specifications

Specifications

Sox9
Murine
Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin),Microscopy,Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL
GMPR9
Human, Mouse
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer