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The 20B7 antibody is reported to recognize human and rat Sox 10, and based on homology should recognize mouse Sox10.Description & Specifications
DescriptionThe monoclonal antibody 20B7 recognizes Sox10, is a member of the Sox superfamily (SRY-related HMG-box) that contain a DNA binding domain (high-mobility group domain) and functions as a transcription factor. Initially, Sox10 expression is localized to the developing neural crest and peripheral nervous system, but later is expressed in glial progenitors and mature oligodendrocytes. Sox10 is involved in stem cell maintenance, melanocyte differentiation, as well as central and peripheral gliogenesis and neurogenesis. Sox10 regulation of downstream proteins such as MASH1, PHOX2B, PDGF-alpha, and MITF is dependent on expression level. Sox10 is also expressed in multipotent vascular stem cells, melanomas, and gliomas.
The 20B7 antibody is reported to recognize human and rat Sox 10, and based on homology should recognize mouse Sox10.
|Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin),Immunohistochemistry (Frozen),Microscopy|
|Store at 2-8°C.|
|SRY-Related HMG-Box Gene 10|
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|