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Sox 10 Mouse, Clone: 20B7, eBioscience™

Mouse Monoclonal Antibody

$172.55 - $404.55

Specifications

Antigen Sox 10
Clone 20B7
Host Species Mouse
Gene Alias SRY-Related HMG-Box Gene 10
Species Reactivity Human, Mouse, Rat
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122700

 
affymetrix
14592380
25μg Each for $172.55

501122701

 
affymetrix
14592382
100μg Each for $404.55
Description & Specifications

Specifications

Antigen Sox 10
Clone 20B7
Host Species Mouse
Gene Alias SRY-Related HMG-Box Gene 10
Species Reactivity Human, Mouse, Rat
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunohistochemistry (Frozen)
Applications Microscopy
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody 20B7 recognizes Sox10, is a member of the Sox superfamily (SRY-related HMG-box) that contain a DNA binding domain (high-mobility group domain) and functions as a transcription factor. Initially, Sox10 expression is localized to the developing neural crest and peripheral nervous system, but later is expressed in glial progenitors and mature oligodendrocytes. Sox10 is involved in stem cell maintenance, melanocyte differentiation, as well as central and peripheral gliogenesis and neurogenesis. Sox10 regulation of downstream proteins such as MASH1, PHOX2B, PDGF-alpha, and MITF is dependent on expression level. Sox10 is also expressed in multipotent vascular stem cells, melanomas, and gliomas.

The 20B7 antibody is reported to recognize human and rat Sox 10, and based on homology should recognize mouse Sox10.