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Snail Mouse anti-Human, Alexa Fluor 488, Clone: 20C8, eBioscience™

Mouse Monoclonal Antibody

$146.52 - $348.48

Specifications

Antigen Snail
Clone 20C8
Host Species Murine
Species Reactivity Human
Applications ELISA,Flow Cytometry (Intracellular Staining),Immunocytochemistry,Immunohistochemistry,Immunohistochemistry (Formalin/Paraffin),Western Blot
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Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501124656 Life Technologies
LS53985980
25μg Each for $146.52
501124657 Life Technologies
LS53985982
100μg Each for $348.48
Specifications

Description

The monoclonal antibody 20C8 recognizes human Snail1, a 29kDa zinc finger transcription factor. Snail1 and Slug both belong to a family of transcription factors that are responsible for inducing epithelial to mesenchymal transition (EMT) during normal organ development and tumor progression. Snail1 expression is localized to both the cytoplasm and nucleus and functions as a transcriptional repressor of E-cadherin, claudins, occludin, and desmoplakin. During embryonic development, Snail1 is localized to the mesoderm, while in the adult, expression is inducible and is usually limited to activated fibroblasts and some mesenchymal cells. Overexpression of Snail1 has been found in carcinomas and fibrosarcomas and may be used as an early marker for EMT.
Description & Specifications

Specifications

Snail
Murine
ELISA,Flow Cytometry (Intracellular Staining),Immunocytochemistry,Immunohistochemistry,Immunohistochemistry (Formalin/Paraffin),Western Blot
Alexa Fluor 488
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
0.5mg/mL
20C8
Human
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer