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Snail Mouse anti-Human, Alexa Fluor 488, Clone: 20C8, eBioscience™

Mouse Monoclonal Antibody

$158.05 - $375.55

Specifications

Antigen Snail
Clone 20C8
Host Species Mouse
Species Reactivity Human
Applications Enzyme Linked Immunosorbent Assay
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501124656

 
affymetrix
53985980
25μg Each for $158.05

501124657

 
affymetrix
53985982
100μg Each for $375.55
Description & Specifications

Specifications

Antigen Snail
Clone 20C8
Host Species Mouse
Species Reactivity Human
Applications Enzyme Linked Immunosorbent Assay
Applications Flow Cytometry (Intracellular Staining)
Applications Immunocytochemistry
Applications Immunohistochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Western Blotting
Regulatory Status RUO
Conjugate Alexa Fluor 488
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody 20C8 recognizes human Snail1, a 29kDa zinc finger transcription factor. Snail1 and Slug both belong to a family of transcription factors that are responsible for inducing epithelial to mesenchymal transition (EMT) during normal organ development and tumor progression. Snail1 expression is localized to both the cytoplasm and nucleus and functions as a transcriptional repressor of E-cadherin, claudins, occludin, and desmoplakin. During embryonic development, Snail1 is localized to the mesoderm, while in the adult, expression is inducible and is usually limited to activated fibroblasts and some mesenchymal cells. Overexpression of Snail1 has been found in carcinomas and fibrosarcomas and may be used as an early marker for EMT.