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Tocris™ SN-6

Selective Na+/Ca2+ exchange inhibitor (reverse mode)

$206.75 - $206.75

Specifications

Product Type SN-6
Inhibitors SN-6
Molecular Weight 402.16
Purity >99
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Disclaimers:

For Research Use Only



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
21-841-0 Tocris™
218410
10mg Each for $206.75
Specifications

Description

Selective Na+/Ca2+-exchange (NCX) inhibitor; displays some selectivity for NCX1. IC50 values are 2.9, 16 and 8.6μM for inhibition of intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Has some affinity for mACh receptors (IC50 = 18μM) but minimal activity against NCKX2 and various receptors and ion channels (IC50 > 30μM). Preferentially blocks Ca2+ influx mode and is more selective for NCX isoforms than KB-R7943 (Cat. No. 1244). Anti-ischemic; potently protects against hypoxia-induced renal tubular cell damage (IC50 = 0.63μM).
  • Chemical Name: 2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester
  • Formula: C20H22N2O5S
  • CAS Number: 415697-08-4
  • Solubility: Soluble to 100mM in DMSO
  • Purity: >99
Description & Specifications

Specifications

SN-6
SN-6
402.16
>99