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Thermo Scientific™ Lab Vision™ SMAD4/DPC4 Ab-1, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ SMAD4/DPC4 Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS865P1ABX

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Catalog No. MS865P1ABX

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Description & Specifications

Specifications

Applications Immunofluorescence
Applications Immunoprecipitation
Applications Western Blotting
Quantity 100µL
Antigen SMAD4/DPC4 Ab-1
Regulatory Status RUO
Immunogen Purified recombinant DPC4 protein
Clone SMD46; same as DCS-46
Cross Reactivity Human
Isotype IgG1
Host Species Mouse
Format Concentrated
Research Discipline Cancer and Tumor Biology
Concentration 1mg/mL
Classification Monoclonal
Conjugate Unlabeled
Type Primary

Provide accurate, reproducible results with the Thermo Scientific™ SMAD4/DPC4 Ab-1, Mouse Monoclonal Antibody.

DPC4 (also named SMAD4; small mothers against decapentaplegic deleted in pancreatic carcinoma). The family of SMAD molecules comprises essential mediators of transforming growth factor β (TGF-β) signaling. To date, seven members of this family have been identified, each of which plays a specific and separate role in mediating TGF-β superfamily gene transcription. At least two different members, Smad2 and Smad4/DPC4, have been implicated in human cancer and appear to have tumor-suppressor functions whose inactivation may play an important role in the histogenesis of pancreatic and colorectal malignancy and possibly other human cancers as well.

Host Species: Mouse

Clone: SMD46; same as DCS-46

Isotype: IgG1

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Purified recombinant DPC4 protein

Molecular Weight: 60kDa

Positive Control: Ls174T, HT29, Raji, Jurkat cells

Cellular Localization: Nuclear

Recommended for:

Western Blotting

Immunofluorescence

Immunoprecipitation (Native and denatured)

Note:

USA: RUO; Int'l: RUO