Thermo Scientific™ Lab Vision™ SMAD4/DPC4 Ab-1, Mouse Monoclonal Antibody
Provide accurate, reproducible results with the Thermo Scientific™ SMAD4/DPC4 Ab-1, Mouse Monoclonal Antibody.
Manufacturer: Thermo Scientific™ Lab Vision™ MS865P1ABX
Provide accurate, reproducible results with the Thermo Scientific™ SMAD4/DPC4 Ab-1, Mouse Monoclonal Antibody.DPC4 (also named SMAD4; small mothers against decapentaplegic deleted in pancreatic carcinoma). The family of SMAD molecules comprises essential mediators of transforming growth factor β (TGF-β) signaling. To date, seven members of this family have been identified, each of which plays a specific and separate role in mediating TGF-β superfamily gene transcription. At least two different members, Smad2 and Smad4/DPC4, have been implicated in human cancer and appear to have tumor-suppressor functions whose inactivation may play an important role in the histogenesis of pancreatic and colorectal malignancy and possibly other human cancers as well.
Host Species: Mouse
Clone: SMD46; same as DCS-46
Species Reactivity: Human. Others not known.
Epitope: Not determined
Immunogen: Purified recombinant DPC4 protein
Molecular Weight: 60kDa
Positive Control: Ls174T, HT29, Raji, Jurkat cells
Cellular Localization: Nuclear
Immunoprecipitation (Native and denatured)
USA: RUO; Int'l: RUO
|SMD46; same as DCS-46|
|Purified recombinant DPC4 protein|
|Cancer and Tumor Biology|