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Thermo Scientific™ Lab Vision™ SMAD4/DPC4 Ab-1, Mouse Monoclonal Antibody

Provide accurate, reproducible results with the Thermo Scientific™ SMAD4/DPC4 Ab-1, Mouse Monoclonal Antibody.

Manufacturer:  Thermo Scientific™ Lab Vision™ MS865P1ABX

 View more versions of this product

Catalog No. MS865P1ABX


 

Specifications

Description

Provide accurate, reproducible results with the Thermo Scientific™ SMAD4/DPC4 Ab-1, Mouse Monoclonal Antibody.

DPC4 (also named SMAD4; small mothers against decapentaplegic deleted in pancreatic carcinoma). The family of SMAD molecules comprises essential mediators of transforming growth factor β (TGF-β) signaling. To date, seven members of this family have been identified, each of which plays a specific and separate role in mediating TGF-β superfamily gene transcription. At least two different members, Smad2 and Smad4/DPC4, have been implicated in human cancer and appear to have tumor-suppressor functions whose inactivation may play an important role in the histogenesis of pancreatic and colorectal malignancy and possibly other human cancers as well.

Host Species: Mouse

Clone: SMD46; same as DCS-46

Isotype: IgG1

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Purified recombinant DPC4 protein

Molecular Weight: 60kDa

Positive Control: Ls174T, HT29, Raji, Jurkat cells

Cellular Localization: Nuclear

Recommended for:

Western Blotting

Immunofluorescence

Immunoprecipitation (Native and denatured)

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

SMAD4/DPC4 Ab-1
Monoclonal
1mg/mL
Human
Murine
IgG1
RUO
Primary
Human
Immunofluorescence,Immunoprecipitation,Western Blotting
SMD46; same as DCS-46
Unlabeled
Concentrated
Purified recombinant DPC4 protein
100μL
Cancer and Tumor Biology
Monoclonal