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Thermo Scientific™ Lab Vision™ SMAD4/DPC4 Ab-1, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ SMAD4/DPC4 Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS865P1ABX

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Catalog No. MS865P1ABX

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Description & Specifications

Specifications

Antigen SMAD4/DPC4 Ab-1
Applications Immunofluorescence
Applications Immunoprecipitation
Applications Western Blotting
Classification Monoclonal
Clone SMD46; same as DCS-46
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Host Species Mouse
Immunogen Purified recombinant DPC4 protein
Isotype IgG1
Quantity 100µL
Regulatory Status RUO
Research Discipline Cancer and Tumor Biology
Type Primary

Provide accurate, reproducible results with the Thermo Scientific™ SMAD4/DPC4 Ab-1, Mouse Monoclonal Antibody.

DPC4 (also named SMAD4; small mothers against decapentaplegic deleted in pancreatic carcinoma). The family of SMAD molecules comprises essential mediators of transforming growth factor β (TGF-β) signaling. To date, seven members of this family have been identified, each of which plays a specific and separate role in mediating TGF-β superfamily gene transcription. At least two different members, Smad2 and Smad4/DPC4, have been implicated in human cancer and appear to have tumor-suppressor functions whose inactivation may play an important role in the histogenesis of pancreatic and colorectal malignancy and possibly other human cancers as well.

Host Species: Mouse

Clone: SMD46; same as DCS-46

Isotype: IgG1

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Purified recombinant DPC4 protein

Molecular Weight: 60kDa

Positive Control: Ls174T, HT29, Raji, Jurkat cells

Cellular Localization: Nuclear

Recommended for:

Western Blotting

Immunofluorescence

Immunoprecipitation (Native and denatured)

Note:

USA: RUO; Int'l: RUO