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sm (Smith Antigen) Ab-1 Mouse Monoclonal Antibody, Epredia™
Epredia™ sm (Smith Antigen) Ab-1, Mouse Monoclonal Antibody provides accurate, reproducible results.
Supplier: Thermo Fisher Scientific MS450R7
Description
The sm (Smith) is an autoantigen on a series of particles composed of RNA and protein. Unlike RNP, the sm antigen is resistant to RNase, but partially sensitive to trypsin. It is involved in the pathogenesis of Systemic lupus erythematosus (SLE). Antibodies to sm are found in 20-30% of patients with SLE.Host Species: Mouse
Clone: Y12
Isotype: IgG3/κ
Species Reactivity: Human, Pig, Rabbit, Rat and Drosophila. Others not known.
Epitope: Not determined
Molecular Weight: ∽25kDa (predominant)
Positive Control: Ls174T cells, Tonsil
Cellular Localization: Nuclear Ab-1 recognizes cross-reactive epitopes on the B'/B and D polypeptides of Sm. Ab-1 precipitates the small nuclear RNAs U1, U2, U4, U5, and U6 providing direct evidence that the Sm antigen resides on all these RNA-protein complexes.
Recommended for:
- Immunohistochemistry (Formalin/paraffin)
- Western Blotting
- Immunofluorescence
- Affinity Purification
- Electron Microscopy
Note:
USA: RUO; Int'l: RUO
Specifications
| sm (Smith Antigen) Ab-1 | |
| Monoclonal | |
| Unconjugated | |
| 7 mL | |
| DNA Repair | |
| Drosophila, Human, Porcine, Rabbit, Rat | |
| IgG3 κ |
| Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot | |
| Y12 | |
| Mouse | |
| RUO | |
| Primary | |
| Prediluted |