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Thermo Scientific™ Lab Vision™ sm (Smith Antigen) Ab-1, Mouse Monoclonal Antibody

Provide accurate, reproducible results with the Thermo Scientific™ sm (Smith Antigen) Ab-1, Mouse Monoclonal Antibody.

Manufacturer:  Thermo Scientific™ Lab Vision™ MS450P1ABX

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Catalog No. MS450P1ABX


 

Specifications

Description

Provide accurate, reproducible results with the Thermo Scientific™ sm (Smith Antigen) Ab-1, Mouse Monoclonal Antibody.

The sm (Smith) is an autoantigen on a series of particles composed of RNA and protein. Unlike RNP, the sm antigen is resistant to RNase, but partially sensitive to trypsin. It is involved in the pathogenesis of Systemic lupus erythematosus (SLE). Antibodies to sm are found in 20-30% of patients with SLE.

Host Species: Mouse

Clone: Y12

Isotype: IgG3/κ

Species Reactivity: Human, Pig, Rabbit, Rat and Drosophila. Others not known.

Epitope: Not determined

Molecular Weight: ∽25kDa (predominant)

Positive Control: Ls174T cells, Tonsil

Cellular Localization: Nuclear Ab-1 recognizes cross-reactive epitopes on the B'/B and D polypeptides of Sm. Ab-1 precipitates the small nuclear RNAs U1, U2, U4, U5, and U6 providing direct evidence that the Sm antigen resides on all these RNA-protein complexes.

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunofluorescence
  • Affinity Purification
  • Electron Microscopy

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

sm (Smith Antigen) Ab-1
Monoclonal
1mg/mL
Ab without BSA/Azide (Frozen)
Murine
100μL
DNA Repair
Monoclonal
Immunofluorescence,Immunohistochemistry (Paraffin),Western Blotting
Y12
Unlabeled
Concentrated
IgG3 kappa
RUO
Primary
Drosophila,Human,Porcine,Rabbit,Rat