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Thermo Scientific™ Lab Vision™ sm (Smith Antigen) Ab-1, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ sm (Smith Antigen) Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS450P1ABX

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Catalog No. MS450P1ABX

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Description & Specifications

Specifications

Host Species Mouse
Antigen sm (Smith Antigen) Ab-1
Cross Reactivity Drosophila
Cross Reactivity Human
Cross Reactivity Porcine
Cross Reactivity Rabbit
Cross Reactivity Rat
Applications Immunofluorescence
Applications Immunohistochemistry (Paraffin)
Applications Western Blotting
Quantity 100µL
Clone Y12
Regulatory Status RUO
Format Concentrated
Isotype IgG3 kappa
Conjugate Unlabeled
Classification Monoclonal
Research Discipline DNA Repair
Formulation Ab without BSA/Azide (Frozen)
Type Primary
Concentration 1mg/mL

Provide accurate, reproducible results with the Thermo Scientific™ sm (Smith Antigen) Ab-1, Mouse Monoclonal Antibody.

The sm (Smith) is an autoantigen on a series of particles composed of RNA and protein. Unlike RNP, the sm antigen is resistant to RNase, but partially sensitive to trypsin. It is involved in the pathogenesis of Systemic lupus erythematosus (SLE). Antibodies to sm are found in 20-30% of patients with SLE.

Host Species: Mouse

Clone: Y12

Isotype: IgG3/κ

Species Reactivity: Human, Pig, Rabbit, Rat and Drosophila. Others not known.

Epitope: Not determined

Molecular Weight: ∽25kDa (predominant)

Positive Control: Ls174T cells, Tonsil

Cellular Localization: Nuclear Ab-1 recognizes cross-reactive epitopes on the B'/B and D polypeptides of Sm. Ab-1 precipitates the small nuclear RNAs U1, U2, U4, U5, and U6 providing direct evidence that the Sm antigen resides on all these RNA-protein complexes.

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunofluorescence
  • Affinity Purification
  • Electron Microscopy

Note:

USA: RUO; Int'l: RUO