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Thermo Scientific™ Slide-A-Lyzer™ 20K MWCO Dialysis Cassettes

Remove buffer salts and contaminants and maximize sample recovery using this semi-permeable membrane with a 20,000-dalton protein MW cut-off (MWCO).

Manufacturer: thermo scientific™  66012

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Catalog No. PI66012


Description & Specifications


Description Slide-A-Lyzer Dialysis Cassettes, 20K MWCO, 12mL
Formulation Cellulose membrane framed in inert plastic
Quantity 8 cassettes
Sufficient For 8 samples, each 3 to 12mL
MWCO 20000 Da
Capacity (Metric) 12mL

Thermo Scientific™ Slide-A-Lyzer Dialysis Cassettes (20K MWCO) facilitate simple and effective removal of buffer salts and small contaminants from proteins and other macromolecules that are larger than 20,000 daltons.

Available in four different cassette sizes to accommodate sample volumes between 0.1 and 30mL, these devices are easier to use than traditional dialysis tubing, providing both faster buffer exchange and more complete sample recovery. Slide-A-Lyzer Cassettes can be used for a wide range of applications including low molecular-weight contaminant removal, buffer exchange, desalting, equilibrium dialysis, and sample concentration.

The cassettes are constructed from two sheets of low-binding, regenerated-cellulose dialysis membrane that are hermetically sealed on either side of a silicone-like gasket inside an inert plastic frame. The membrane and cassette materials are compatible with most common laboratory chemicals and buffers. Liquid samples are easily added and removed by penetrating the self-sealing gasket with a hypodermic needle attached to a syringe. No knots, clips or caps are needed to seal the units and prevent leaking and sample-loss during the dialysis procedure.


  • Easy to use – no knots or clamps are needed; just inject sample into cassette and begin dialysis

  • Fast dialysis – flat cassette chamber with two membranes provides high surface-area to volume ratio that maximizes diffusion rate compared to cylindrical dialysis tubing

  • High recovery – rectangular cassette design maximizes recovery of entire sample volume via any one of the four corner injection ports

  • Four cassette sizes – select the cassette that best suits your sample volume

  • Color-coded – purple cassette frame specifies cassettes with the 20,000 MW pore size membrane

20K Dialysis Membrane Specifications:

  • Composition: Regenerated cellulose synthesized by the Viscose method
  • Thickness: 0.9 to 1.2mil (22.5 to 30μm)
  • Hydration Required Before Use: 2 minutes
  • Glycerol Content: None
  • Sulfur Content: 0.04%
  • Heavy Metals Content: Trace

Item-Specific Features:

  • 30mL cassette has built-in air chamber for flotation