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SLAM Associated Protein (SAP) Rat anti-Human, PE, Clone: XLP-1D12, eBioscience™

Rat Monoclonal Antibody

$183.48 - $460.68

Specifications

Antigen SLAM Associated Protein (SAP)
Clone XLP-1D12
Host Species Rat
Gene Alias SH2D1A
Applications Flow Cytometry (Intracellular Staining)
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122459 Life Technologies
LS12978741
25 Tests Each for $183.48
501122460 Life Technologies
LS12978742
100 Tests Each for $460.68
Specifications

Description

The monoclonal antibody XLP-1D12 reacts with human SLAM-associated protein (SAP), which is also known as SH2D1A. SAP is a 15kDa SH2 domain-containing adaptor protein. Upon CD150/SLAM family receptor ligation, SAP recruits Fyn tyrosine kinase, which phosphorylates the receptor to activate downstream signaling events. SAP is expressed in thymocytes, T cells, NK cells, and NKT cells. Studies have demonstrated a role for SAP in promoting follicular T helper cell differentiation during germinal center formation. In addition, this protein is involved in NKT cell development, Th1/Th2 differentiation, development of innate T cells, and regulation of NK cell and CD8+ T cell cytotoxicity. Mutations of the gene encoding SAP results in X-linked lymphoproliferative (XLP) syndrome, which is characterized by impaired humoral immunity leading to increased susceptibility to Epstein-Barr virus infection and/or lymphoma. SAP has also been linked to automimmune diseases such as systemic lupus erythematosus.
Description & Specifications

Specifications

SLAM Associated Protein (SAP)
Rat
Flow Cytometry (Intracellular Staining)
PE
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
5μL (0.5μg)/test
XLP-1D12
SH2D1A
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer