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Sino Biological™ IgG1-Fc Recombinant Human Protein DFS Item


This recombinant human protein is expressed from a DNA sequence encoding the human IgG1-Fc region (AAC82527.1), containing residues 99 to 330, including a 103 Cys/Ser mutation

Manufacturer: life technologies  LS10702HNAH5

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 Disclaimers

For Research Use Only. Not for use in diagnostic procedures.

Catalog No. 10702HNAH5

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Description & Specifications

Specifications

Molecular Weight 26kDa
Storage Requirements Store at -20° to -70°C. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles. Expires one year from date of receipt when stored as instructed.
Format Lyophilized
Common Name Fc region of human immunoglobulin G1
Validated Application Assay Standard
Protein Subtype Other Proteins
Quantity 5μg
Gene Symbol IgG1-Fc
Protein Family Growth Factors & Receptors
Protein Tag IgG1 Fc Tag
For Use With (Application) Proteins, Expression, Isolation & Analysis; Enzyme & Protein Activity Assays; Cell Analysis; Immunoassays; Protein Assay Controls, Reference Standards & Accessories; Build-Your-Own Immunoassay
Purity ≥95% by SDS-PAGE
Structural Form Truncated/Recombinant
Gene Alias Fc region of human immunoglobulin G1
Expression System Mammalian
Endotoxin Concentration <1 EU/μg

Immunoglobulin gamma-1 heavy chain constant region, partial (IgG1-Fc), recombinant human protein is supplied as a lyophilized powder. In general, recombinant proteins can be used as protein standard and in cell biology research applications.&line-break;Background: Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells, and constitutes 75% of serum immunoglobulins in humans. IgG antibodies protect the body against the pathogens by agglutination and immobilization, complement activation, toxin neutralization, as well as the antibody-dependent cell-mediated cytotoxicity (ADCC). Recombinant IgG Fc is suggested to represent a potential anti-inflammatory drug for treatment of human autoimmune diseases.

  • N-terminal Sequence Analysis: Glu 99
  • Activity: 1. Measured by its ability to bind human CD16a-His (Mfr. No. 10389-H08H1) in a functional ELISA; 2. Measured by its ability to bind human CD16a-AVI-His (Mfr. No. 10389-H27H) in a functional ELISA; 3.Measured by its ability to bind human CD16a-His (Mfr. No. 10389-H08H) in a functional ELISA
  • Formulation: lyophilized in PBS, pH 7.4, 5% mannitol, 5% trehalose, and 0.02% Tween®-80
  • Reconstitution: Dissolve the protein in sterile double-distilled water to a concentration of 0.2mg/mL or lower; aliquot and use as soon as possible

Shipping Condition: Room Temperature