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Sino Biological™ CD19 Recombinant Human Protein, His Tag DFS Item

This recombinant protein is expressed from a DNA sequence encoding the extracellular domain (Met 1-Lys 291) of human CD19 (AAB60697) fused to a polyhistidine tag at the C-terminus

$161.70 - $2,215.50

Specifications

Purity ≥90% by SDS-PAGE
Endotoxin Concentration <1 EU/μg
Format Lyophilized
Gene Alias B4, mgC12802
Gene ID (Entrez) 930
View More Specs

 Disclaimers

For Research Use Only. Not for use in diagnostic procedures.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

11880H08H25

DFS Item
 
life technologies
LS11880H08H25
5 x 5μg Each for $417.90

11880H08HL

DFS Item
 
life technologies
LS11880H08H250
5 x 50μg Each for $2,215.50

11880H08H5

DFS Item
 
life technologies
LS11880H08H5
5μg Each for $161.70

11880H08H50

DFS Item
 
life technologies
LS11880H08H50
50μg Each for $688.80
Description & Specifications

Specifications

Purity ≥90% by SDS-PAGE
Endotoxin Concentration <1 EU/μg
Format Lyophilized
Gene Alias B4, mgC12802
Gene ID (Entrez) 930

Cluster of Differentiation 19 (CD19) recombinant human protein is supplied as a lyophilized powder. This protein is suitable for use in analysis of protein structure the study of protein-protein interactions, and cell biology research applications. It can also be used as an immunogen, or as a protein standard.&line-break;Background: Cluster of Differentiation 19 (CD19), is a single-pass type I membrane protein which contains two Ig-like C2-type (immunoglobulinlike) domains. CD19 forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. It interacts with VAV. It interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. CD19 also interacts with PLCG2 when phosphorylated on Tyr-409. CD19 is an important pan B cell marker and co-stimulatory protein in humans and mice. CD19 is a hallmark differentiation antigen of the B cell lineage and positively regulates antigen receptor signal transduction in mature B cells. CD19 defines signaling thresholds for the Ag receptor as well as other cell surface receptors that regulate B lymphocyte selection, activation, and differentiation. Defects in CD19 are a cause of hypogammaglobulinemia.

  • N-terminal Sequence Analysis: Pro 20
  • Activity: Measured by its binding ability in a functional ELISA; immobilized human CD19 at 2μg/mL (100μL/well) has been shown to bind biotinylated human CD9 with a linear range of 0.032-0.8μg/mL
  • Formulation: lyophilized in PBS, pH 7.4, 5% mannitol, 5% trehalose, and 0.02% Tween®-80
  • Reconstitution: Dissolve the protein in sterile double-distilled water to a concentration of 0.2mg/mL or lower; aliquot and use as soon as possible

Shipping Condition: Room Temperature. Manufactured by Sino Biological (China).