Invitrogen™ SIK3 Recombinant Human Protein
SIK3 (QSK) is a serine/threonine-protein kinase, belongs to QIK subfamily. Recombinant human SIK3 (1-307) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Manufacturer: Invitrogen™ LSPV6403
The phosphorylation of SIK3 by LKB1 through the 14-3-3 binding enhances its catalytic activity and leads its localization to punctate structures within the cytoplasm. Overexpression of SIK3 promotes G1/S cell cycle progression with ovarian cancer. There are two sites (H331L and A1103V) were mutated at significant frequency in breast cancer. SIK3 is a novel tumor-associated antigen (TAA).
- Validated in LanthaScreen™ Kinase Binding Assay
- Protocols available for simple use and optimized performance
- Multiple pack sizes available for convenient use
|Target & Lead Identification & Validation|Kinase Biology|Kinase Proteins & Expression Reagents|Protein Biology|Enzyme & Protein Activity Assays|Kinase Activity|Protein Assays and Analysis|Industrial & Applied Science|Pharma & Biopharma|
|Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws.|
|50mM Tris-HCl pH 7.5, 150mM NaCl, 0.25mM DTT, 10mM glutathione, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol|
|QSK, SIK-3, L19, FLJ12240, KIAA0999|