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Siglec H Rat anti-Mouse, PerCP-eFluor 710, Clone: eBio440c, eBioscience™

Rat Monoclonal Antibody

$158.05 - $158.05

Specifications

Antigen Siglec H
Clone eBio440c
Host Species Rat
Gene Alias Sialic Acid-Binding Immunoglobulin-Like Lectin H
Species Reactivity Mouse
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5015953

 
affymetrix
46033380
25μg Each for $158.05
Description & Specifications

Specifications

Antigen Siglec H
Clone eBio440c
Host Species Rat
Gene Alias Sialic Acid-Binding Immunoglobulin-Like Lectin H
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PerCP-eFluor 710
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The monoclonal antibody eBio440c recognizes Siglec-H, a protein exclusively found on pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naïve mouse. Mouse IPC are typically PDCA+, CD11c+, CD11b-, B220+, and Ly-6C+, and are quick to respond to viruses. Siglec-H is a transmembrane protein of the Ig superfamily that like CD33 have been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM domain (immunoreceptor tyrosine based inhibitory motif). To overcome the lack of a cytoplasmic domain, Siglec-H associates with DAP12 thereby allowing for signal transduction.

The eBio440c antibody has been shown to inhibit pDC function (inhbits IFNalpha secretion in response to CpG).

It has been observed that some mouse strains (such as SJL) have higher percentages of pDCs compared to C57BL/6.