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siglec H Rat anti-Mouse, eFluor 660, Clone: eBio440c, eBioscience™

Rat Monoclonal Antibody

$157.08 - $368.28

Specifications

Antigen siglec H
Clone eBio440c
Host Species Rat
Gene Alias Sialic Acid-Binding Immunoglobulin-Like Lectin H
Applications Flow Cytometry
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501124266 Life Technologies
LS50033380
25μg Each for $157.08
501124267 Life Technologies
LS50033382
100μg Each for $368.28
Specifications

Description

The monoclonal antibody eBio440c recognizes Siglec-H, a protein exclusively found on pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naïve mouse. Mouse IPC are typically PDCA+, CD11c+, CD11b-, B220+, and Ly-6C+, and are quick to respond to viruses. Siglec-H is a transmembrane protein of the Ig superfamily that like CD33 have been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM domain (immunoreceptor tyrosine based inhibitory motif). To overcome the lack of a cytoplasmic domain, Siglec-H associates with DAP12 thereby allowing for signal transduction.

The eBio440c antibody has been shown to inhibit pDC function (inhbits IFNalpha secretion in response to CpG).

It has been observed that some mouse strains (such as SJL) have higher percentages of pDCs compared to C57BL/6.
Description & Specifications

Specifications

siglec H
Rat
Flow Cytometry
eFluor 660
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
0.2mg/mL
eBio440c
Sialic Acid-Binding Immunoglobulin-Like Lectin H
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer