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Siglec G Mouse anti-Mouse, PerCP-eFluor 710, Clone: SH2.1, eBioscience™

Mouse Monoclonal Antibody

$187.05 - $477.05

Specifications

Antigen Siglec G
Clone SH2.1
Host Species Mouse
Gene Alias sialic acid-binding immunoglobulin-like lectin-G
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123841

 
affymetrix
46583380
25μg Each for $187.05

501123842

 
affymetrix
46583382
100μg Each for $477.05
Description & Specifications

Specifications

Antigen Siglec G
Clone SH2.1
Host Species Mouse
Gene Alias sialic acid-binding immunoglobulin-like lectin-G
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PerCP-eFluor 710
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The SH2.1 monoclonal antibody reacts with mouse siglec-G, which is also known as sialic acid-binding immunoglobulin-like lectin-G. Siglec-G is an inhibitory receptor that is expressed in a B cell-specific manner with B1 B cells expressing the highest levels of siglec-G. When overexpressed, siglec-G inhibits B cell receptor-mediated calcium signaling. Siglec-G-deficient mice show a massive expansion of the B1a cell population as well as higher titers of natural IgM antibodies. Siglec-G-deficient B1a cells show a lower level of spontaneous apoptosis and a prolonged life span, which may result from higher expression levels of the transcription factor NFATc1. Siglec-G-dependent negative regulation exists in B1 cells, which may explain the naturally muted signaling response of B1 cells.