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Siglec G Mouse anti-Mouse, PerCP-eFluor 710, Clone: SH2.1, eBioscience™

Mouse Monoclonal Antibody

$170.28 - $434.28

Specifications

Antigen Siglec G
Clone SH2.1
Host Species Murine
Gene Alias sialic acid-binding immunoglobulin-like lectin-G
Species Reactivity Mouse
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501123841 Life Technologies
LS46583380
25μg Each for $170.28
501123842 Life Technologies
LS46583382
100μg Each for $434.28
Specifications

Description

The SH2.1 monoclonal antibody reacts with mouse siglec-G, which is also known as sialic acid-binding immunoglobulin-like lectin-G. Siglec-G is an inhibitory receptor that is expressed in a B cell-specific manner with B1 B cells expressing the highest levels of siglec-G. When overexpressed, siglec-G inhibits B cell receptor-mediated calcium signaling. Siglec-G-deficient mice show a massive expansion of the B1a cell population as well as higher titers of natural IgM antibodies. Siglec-G-deficient B1a cells show a lower level of spontaneous apoptosis and a prolonged life span, which may result from higher expression levels of the transcription factor NFATc1. Siglec-G-dependent negative regulation exists in B1 cells, which may explain the naturally muted signaling response of B1 cells.
Description & Specifications

Specifications

Siglec G
Murine
Mouse
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
SH2.1
sialic acid-binding immunoglobulin-like lectin-G
Flow Cytometry
PerCP-eFluor 710
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
0.2mg/mL