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Tocris™ SIB 1893


mGlu5 antagonist and positive allosteric modulator at mGlu4

Manufacturer: tocris™  1214/10

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 Disclaimers

For Research Use Only

Catalog No. 1214/10

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Description & Specifications

Specifications

Product Type SIB 1893
Inhibitors SIB 1893
Molecular Weight 195.26
Quantity 10mg

A highly selective non-competitive antagonist for the metabotropic glutamate mGlu5 receptor subtype; displays an IC50 value of 0.3μM at hmGlu5, compared with > 100μM at hmGlu1b, hmGlu2, hmGlu6, hmGlu7 and hmGlu8. Centrally active upon systemic administration in vivo. Positive allosteric modulator at mGlu4 receptors.

  • Chemical Name: 2-Methyl-6-(2-phenylethenyl)pyridine
  • Formula: C14H13N
  • CAS Number: 6266-99-5
  • Solubility: Soluble to 100mM in DMSO