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Tocris™ SIB 1893

mGlu5 antagonist and positive allosteric modulator at mGlu4

$165.79 - $700.43

Specifications

Product Type SIB 1893
Inhibitors SIB 1893
Molecular Weight 195.26
View More Specs

 Disclaimers

For Research Use Only

Products
Catalog Number Mfr. No. Quantity Price Quantity    

1214/10

 
tocris™
1214/10
10mg Each for $165.79

121450R

 
tocris™
1214/50
50mg Each for $700.43
Description & Specifications

Specifications

Product Type SIB 1893
Inhibitors SIB 1893
Molecular Weight 195.26

A highly selective non-competitive antagonist for the metabotropic glutamate mGlu5 receptor subtype; displays an IC50 value of 0.3μM at hmGlu5, compared with > 100μM at hmGlu1b, hmGlu2, hmGlu6, hmGlu7 and hmGlu8. Centrally active upon systemic administration in vivo. Positive allosteric modulator at mGlu4 receptors.

  • Chemical Name: 2-Methyl-6-(2-phenylethenyl)pyridine
  • Formula: C14H13N
  • CAS Number: 6266-99-5
  • Solubility: Soluble to 100mM in DMSO