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Thermo Scientific™ Lab Vision™ SHP-1 Ab-1, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ SHP-1 Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS1190P1ABX

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Catalog No. MS1190P1ABX

  • / Each
 

Description & Specifications

Specifications

Host Species Mouse
Isotype IgG2b kappa
Cross Reactivity Human
Regulatory Status RUO
Applications Western Blotting
Clone 1SH01; same as 11D7C8H5
Immunogen Recombinant human SHP1 protein
Format Concentrated
Antigen SHP-1 Ab-1
Quantity 100µL
Classification Monoclonal
Conjugate Unlabeled
Research Discipline Signal Transduction
Concentration 1mg/mL
Type Primary

Provide accurate, reproducible results with the Thermo Scientific™ SHP-1 Ab-1, Mouse Monoclonal Antibody.

Shp-1 is a SH2-containing protein-tyrosine phosphatase 1 (SHP-1). SHP-1 is known to play a crucial role in the regulation of hematopoiesis and it regulates the transcriptional activity stimulated by the erythropoietin (EPO)-induced JAK/STAT and MAPK pathways and is involved in the signaling machinery responsible for erythroid differentiation and suppression of apoptosis. Furthermore, the observation that SHP-1 associates with RAFTK/Pyk2/CAK activated by β-chemokine receptor (CCR5) and SHP-1 also associates with the adaptor protein Grb2 and the Src-related kinase Syk indicates the role of SHP-1 in modulating cell migration, proliferation, and immune functions.

Host Species: Mouse

Clone: 1SH01; same as 11D7C8H5

Isotype: IgG2b/κ

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Recombinant human SHP-1 protein

Molecular Weight: ∽68kDa

Positive Control: Jurkat or HeLa cells

Cellular Localization: Cytoplasmic

Recommended for:

  • Western Blotting
  • Immunoprecipitation (Not verified)

Note:

USA: RUO; Int'l: RUO