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Tocris™ SB 525334

Selective inhibitor of TGF-betaRI

$250.62 - $1,052.58

Specifications

Product Type SB 525334
Inhibitors SB 525334
Molecular Weight 343.42
Purity >97
View More Specs

 Disclaimers

For Research Use Only

Products
Catalog Number Mfr. No. Quantity Price Quantity    

321110

 
tocris™
3211/10
10mg Each for $250.62

321150

 
tocris™
3211/50
50mg Each for $1,052.58
Description & Specifications

Specifications

Product Type SB 525334
Inhibitors SB 525334
Molecular Weight 343.42
Purity >97

Selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells. Attenuates bleomycin-induced pulmonary fibrosis.

  • Chemical Name: 6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline
  • Formula: C21H21N5
  • CAS Number: 356559-20-1
  • Solubility: Soluble to 100mM in DMSO and to 100mM in 1eq. HCl
  • Purity: >97