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Thermo Scientific™ Lab Vision™ Retinoblastoma (Rb) (Phospho-specific Serine) Ab-7, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ Retinoblastoma (Rb) (Phospho-specific Serine) Ab-7, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS1883P1ABX

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Catalog No. MS1883P1ABX

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Description & Specifications

Specifications

Antigen Retinoblastoma (Rb) (Phospho-specific Serine) Ab-7
Applications Western Blotting
Classification Monoclonal
Clone 51B7
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Format Concentrated
Host Species Mouse
Isotype IgG1
Quantity 100µL
Regulatory Status RUO
Research Discipline Cancer and Tumor Biology
Type Primary

Provide accurate, reproducible results with the Thermo Scientific™ Retinoblastoma (Rb) (Phospho-specific Serine) Ab-7, Mouse Monoclonal Antibody.

Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia. Phosphorylation of Rb at S608 depends on CDK4.

Host Species: Mouse

Clone: 51B7

Isotype: IgG1

Species Reactivity: Human and Mouse. Others not known.

Molecular Weight: 105kDa

Positive Control: Ls174T cells

Cellular Localization: Nuclear Ab-7 reacts with human and mouse protein phosphorylated on S608. It does not react with nonphosphorylate Rb or Rb phosphorylated at other sites.

Recommended for:

  • Western Blotting

Note:

USA: RUO; Int'l: RUO