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Thermo Scientific™ Lab Vision™ Retinoblastoma (Rb) (Phospho-specific Serine) Ab-7, Mouse Monoclonal Antibody

Provide accurate, reproducible results with the Thermo Scientific™ Retinoblastoma (Rb) (Phospho-specific Serine) Ab-7, Mouse Monoclonal Antibody.

Manufacturer:  Thermo Scientific™ Lab Vision™ MS1883PABX

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Catalog No. MS1883PABX


 

Specifications

Description

Provide accurate, reproducible results with the Thermo Scientific™ Retinoblastoma (Rb) (Phospho-specific Serine) Ab-7, Mouse Monoclonal Antibody.

Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia. Phosphorylation of Rb at S608 depends on CDK4.

Host Species: Mouse

Clone: 51B7

Isotype: IgG1

Species Reactivity: Human and Mouse. Others not known.

Molecular Weight: 105kDa

Positive Control: Ls174T cells

Cellular Localization: Nuclear Ab-7 reacts with human and mouse protein phosphorylated on S608. It does not react with nonphosphorylate Rb or Rb phosphorylated at other sites.

Recommended for:

  • Western Blotting

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

Retinoblastoma (Rb) (Phospho-specific Serine) Ab-7
Monoclonal
1mg/mL
Human,Mouse
Murine
200μL
Cancer and Tumor Biology
Monoclonal
Western Blot
51B7
Unlabeled
Concentrated
IgG1
RUO
Primary
Human,Murine